429 Case report: Pemphigus vulgaris mimicking dermatitis herpetiformis
نویسندگان
چکیده
A 23-year-old woman with a history of interstitial lung disease, positive ANA, and weakly anti-Scl-70 presented periumbilical blisters. Biopsy revealed subepidermal split eosinophils neutrophils suprabasilar acantholysis. Intercellular C3 on direct immunofluorescence (DIF) was suggestive pemphigus vulgaris (PV). She subsequently developed tense vesicle her right shin. Repeat biopsy only demonstrated intraepidermal blister re-epithelialization floor. Her bullae were pauci-inflammatory not histologically classic. Two months later, the patient returned intensely pruritic painful grouped vesicles scattered pink papules trunk extremities, along back. This eruption had appearance dermatitis herpetiform (DH) however tissue transglutaminase, deamidated gliadin peptide, endomysial antibodies negative. third showed acantholysis intercellular IgG DIF she later ulceration lower lip all supporting diagnosis PV. Mycophenolate mofetil prolonged oral prednisone taper resulted in significant improvement cutaneous mucosal lesions. PV classically presents flaccid blisters showing deposits. DH typically as erythematous papulovesicular rash over extensor surfaces, buttocks, knees. Previously described herpetiformis combines clinical histologic pemphigus. Unlike our patient, this entity usually has urticarial lesions eosinophilic spongiosis. case highlights an example that clinically mimicked DH. It also serves reminder to repeat biopsies when there is conflicting clinical-pathologic correlation order optimize care management.
منابع مشابه
Pemphigus herpetiformis with progression to pemphigus foliaceus: a case report.
Pemphigus herpetiformis (PH) is an uncommon variant of pemphigus that accounts for an estimated 6% to 7.2% of all cases of this skin disorder. The term pemphigus herpetiformis was coined by Jablonska et al. in 1975 to describe a entity that was clinically similar to dermatitis herpetiformis, showed acantholysis on biopsy, and responded to sulfapyridine. The authors considered that PH was a vari...
متن کاملTinea incognito simulating dermatitis herpetiformis: An unusual case report
Tinea incognito is a dermatophyte infection of the skin with an atypical presentation attributed to inappropriate treatment with immunosuppressive medications. In thi
متن کاملChildhood pemphigus vulgaris: a case report
Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous blistering disease. Although PV occurs predominantly in adulthood, in the 3rd to 5th decades of life, there have rarely been reports of childhood cases which are often misdiagnosed. It presents as oral blisters that rupture rapidly and progress to painful erosions. Most patients develop cutaneous flaccid blisters that ruptu...
متن کاملA Case Report of Neonatal Pemphigus vulgaris
Pemphigus vulgaris (PV) is a chronic, rare mucocutaneous autoimmune bullous diseases characterized by flaccid blisters and/or pustules, with secondary erosions of the mucous membranes / skin. Pemphigus vulgaris is threatening patient life by the formation of splits within the epidermis, accompanied by acantholysis (separation of keratinocytes from each other). In this article, a term female neo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.438